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Antioxidant micronutrients; glucosamine and chondroitin products; nutritional supplements; osteoarthritis; vitamins 1. Speculative lay publications on this subject proliferate, and health food stores offer an excess of nutritional supplements represented as therapies for arthritis 1. The over-the-counter consumption of such nutritional remedies is significant, with From: Nutrition and Rheumatic Disease Edited by: Thus, there is a need for safe and effective alternative therapies as well as preventive strategies.

Such processes include oxidative damage, cartilage matrix degradation and repair, and chondrocyte function and response in adjacent bone.

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With more advanced disease, pain may be noted with progressively less activity, eventually occurring at rest and at night. Morning stiffness typically resolves less than 30 minutes after a patient awakens, but may recur following periods of inactivity, a phenomenon termed gelling. Osteophytes may be palpable as bony enlargements along the periphery of the joint.

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